Cremophor EL is the registered trademark of BASF Corp. for
its version of polyethoxylated castor oil.
Cremophor EL is prepared by reacting 35 moles of ethylene oxide with each mole of
castor oil. The finished product is a mixture :the essential component is the
material in which the hydroxyl groups of the castor oil triglyceride have
ethoxylated with ethylene oxide to form polyethylene glycol ethers. Minor
components are the polyethyelene glycol esters of ricinoleic acid,
polyethyelene glycols and polyethyelene glycol ethers of glycerol.
Cremophor EL is a synthetic, nonionic
surfactant.
Cremophor EL 's utility
comes from
Cremophor EL 's ability to stabilize emulsions of nonpolar
materials in aqueous systems.
Cremophor EL is an excipient or additive in drugs.
Therapeutically, modern drugs are rarely given in a pure chemical state, so
most active ingredients are combined with excipients or additives such as
Cremophor EL .
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